Table 4.
Multivariate logistic regression of the joint effect of hypertension and hyperuricemia for ischemic stroke by sex
| Odds Ratio (95%CI) | ||||||
|---|---|---|---|---|---|---|
| Model 1 | P value | Model 2 | P value | Model 3 | P value | |
| Men | ||||||
| HTN (−) HUA (−) | 1 (reference) | 1 (reference) | 1 (reference) | |||
| HTN (−) HUA (+) | 2.516 (1.055, 6.000) | 0.037 | 3.133 (1.299, 7.556) | 0.011 | 2.890 (1.173, 7.121) | 0.021 |
| HTN (+) HUA (−) | 5.498 (3.409, 8.866) | < 0.001 | 3.777 (2.317, 6.157) | < 0.001 | 3.296 (1.998, 5.437) | < 0.001 |
| HTN (+) HUA (+) | 5.917 (3.276, 10.688) | < 0.001 | 4.827 (2.642, 8.819) | < 0.001 | 4.059 (2.126, 7.751) | < 0.001 |
| P value for interaction | 0.007 | 0.011 | 0.073 | |||
| Women | ||||||
| HTN (−) HUA (−) | 1 (reference) | 1 (reference) | 1 (reference) | |||
| HTN (−) HUA (+) | 2.136 (0.491, 9.284) | 0.312 | 1.694 (0.387, 7.421) | 0.484 | 1.353 (0.306, 5.991) | 0.691 |
| HTN (+) HUA (−) | 8.956 (5.465, 14.677) | < 0.001 | 5.492 (3.309, 9.114) | < 0.001 | 4.592 (2.740, 7.696) | < 0.001 |
| HTN (+) HUA (+) | 24.254 (13.688, 42.976) | < 0.001 | 12.689 (7.027, 22.912) | < 0.001 | 8.913 (4.726, 16.809) | < 0.001 |
| P value for interaction | < 0.001 | < 0.001 | < 0.001 | |||
Model 1: no adjust
Model 2: adjust for age, current smoking, current drinking
Model 3: adjust for age, current smoking, current drinking, BMI, FPG, TC, TG, HDL-C, LDL-C, eGFR
Abbreviations: BMI body mass index, FPG fasting plasma glucose, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, eGFR estimated glomerular filtration rate