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. Author manuscript; available in PMC: 2021 Apr 23.
Published in final edited form as: Eur J Epidemiol. 2018 Apr 4;33(5):485–495. doi: 10.1007/s10654-018-0382-z

Table 4.

Associations of a genetic risk sore for BMI with leukocyte telomere length and mitochondrial DNA copy number among women in the Nurses’ Health Study

GRS quartile 1 GRS quartile 2 GRS quartile 3 GRS quartile 4 P for trend
TL z-score
 N 1035 1034 1037 1049
 Mean (SD)1 −.04(.99) −.01(.95) −.05(1.03) .04(1.00)
 OR of lower score (95% CI)2 Ref 1.01(.85, 1.20) .98(.82, 1.17) .91(.77, 1.08) .26
 P2 - .93 .82 .28
mtCN z-score
 N 405 392 412 387
 Mean (SD)1 .01(.93) .06(.97) −.02(1.00) −.03(.94)
 OR of lower score (95% CI)2 Ref .90(.68, 1.19) 1.08(.82, 1.43) 1.24(.94, 1.64) .07
 P2 - .46 .57 .13
1

Standardized by age at blood collection.

2

Unconditional logistic regression models with adjustment for age at blood collection. TL and mtCN z-score outcomes were dichotomized at the median.

Abbreviations: BMI, body mass index; GRS, genetic risk score; SD, standard deviation; OR, odds ratio; CI, confidence interval; Ref, reference; TL, telomere length; mtCN, mitochondrial DNA copy number.