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Dose-dependent AU-011 tumor killing in vivo. AU-011 was systemically administered to nude mice with subcutaneous 92.1 tumors (40–80 mm3). After 12 hours, animals were exposed to 25 or 50 J/cm2 690 nm light. Tumors were removed after 24 hours, homogenized, and viability measured by flow cytometry. Vehicle, n = 3; AU-011, n = 5. Data are representative of two experiments. Two-tailed Student t test: *, P = 0.0091; **, P = 0.0071.
