Fig. 1 |. comparison of PP2a complexes from four major B subunit families.

a, representative architectures of PP2A holoenzyme complexes from each family (B, B′, B′′ and B′′′). The catalytic active site is marked by a star on the C subunit. b, Superposition of A subunits at the constant A–C dimeric interface reveals flexibility at the distal N terminus of the scaffolding A subunit for each PP2A family member. PP2A A–C conformations in the context of different B-subunit-containing complexes are color coded and labeled. The overlay of subunits is shown as two different views, rotated around the vertical axis as indicated. Structures and overlays were generated using PDB IDs 3DW8 (B–PP2A), 2IAE (B′–PP2A), 4I5L (B′′–PP2A), 7K36 (B′′′–PP2A) and 2IE4 (A–C dimer).