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During prosurvival signaling, STrIPAK inhibits the hippo signaling pathway by dephosphorylating and inactivating MST1/2. This allows unphosphorylated YAP1 to transcribe pro-growth proteins. In the absence of STrIPAK, hippo signaling proceeds, allowing phosphorylated MST1/2 to activate LATS1/2–MOB1, which phosphorylates YAP1. 14-3-3 binds to phosphorylated YAP1, leading to its degradation (image generated using Biorender).
