Figure 3. Whole-Exome Sequencing and Phylogenetic Tree Reconstruction, Compatible With the Glial Origin of the Distant Lesions.

(A) Phylogenetic tree with parallel evolution events harboring different mutations occurring between the primary and secondary tumors. (B) Map summarizing all standard normal variable (SNV), insertions and deletions per lesion, and their pathogenic role in known tumor driver genes. (C) A heatmap of copy number variations (CNVs) showing losses (blue) and gains (red).