Figure 6. Predictions of Protein Stability and 3D Structure of NOTCH3 Mutations.

(A) Prediction of the protein stability change expressed in Kcal/mol for the A1604T, L1515P, and L1519P NOTCH3 mutations. (B) Predicted 3D structures of the NRR domain of the NOTCH3 wild-type and A1604T receptors. The alanine (left) and threonine (right) are visualized in the boxed area (see also figure e-7, links.lww.com/NXG/A415). NRR = negative regulatory region.