Figure 2.

Menstrual cycle effect on endometrial gene expression in transcriptomic studies by Burney 2006, Hawkins 2011, Koot 2016 and Tamaresis 2014. For each study (A–D), the result of the principal component analysis is plotted for the first three components before and after applying the menstrual cycle effect correction to evaluate whether the samples are primarily grouped by the menstrual cycle phase of endometrial biopsy collection (colour code) and/or by the uterine disorder (shape code) based on their gene expression profiles. PC, principal component. PF, proliferative. ESE, early secretory. MSE, mid-secretory. SE, secretory. LH, luteinising hormone. RIF, recurrent implantation failure.