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. 2021 Feb 12;27(4):gaab011. doi: 10.1093/molehr/gaab011

Figure 6.

Figure 6.

Functional roles of the newly discovered potential biomarkers of endometriosis and recurrent implantation failure (A) and recurrent implantation failure (RIF) (B). Functions associated with the new biomarkers of endometriosis (A) (eutopic: n = 544, ectopic: n = 158) and RIF (n = 27) (B) are shown in the endometrial cellular context together with references supporting the role of each function in the pathophysiology of the corresponding disorder. The number of biomarkers of eutopic (A, purple boxes) and ectopic (A, green boxes) endometriosis and RIF (B, pink boxes) annotated to each function are represented. New potential biomarkers belonging to each represented function are fully listed in Supplementary Table SIII. Functional annotations were performed for each new biomarker using Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways (Ogata et al., 1999) and Gene Ontology (GO) (Ashburner et al., 2000) databases. For GO annotation, the three ontologies were used (biological processes, molecular functions, cellular components), only experimental-evidenced GO-gene associations were included, a propagated GO version was used for considering the whole GO-tree structure, and annotated GO terms were filtered by those having more than five and less than 500 associated genes. Obtained GO and KEGG annotated terms were then grouped in broader functional categories, which are represented in this figure. Keywords used in PubMed to search for functions altered in endometriosis and RIF patients included ‘endometriosis’, ‘RIF’, ‘recurrent implantation failure’, ‘function’, ‘pathway’, ‘gene ontology’ and ‘KEGG’. References: a—(Devesa-Peiro et al., 2020); b—(Burney et al., 2007); c—(Crispi et al., 2013); d—(Anderson, 2019); e—(Burney and Giudice, 2012); f—(Liu et al., 2015); g—(Marquardt et al., 2019); h—(Patel et al., 2018); I—(Tomassetti et al., 2006); j—(Zhang et al., 2019); k—(Cakmak and Taylor, 2011); l—(Koot et al., 2016); m—(Pathare et al., 2017); n—(Huang et al., 2017); o—(Long et al., 2016); p—(Hapangama et al., 2008); q—(Attar et al., 2010); r—(von Adamek et al., 2005); s—(Kiyomizu et al., 2006).