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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Cell Signal. 2020 Apr 20;73:109647. doi: 10.1016/j.cellsig.2020.109647

Figure 3. Most renal innate immune cell types are evolutionarily conserved across mammalian species.

Figure 3.

The above proportions were obtained from unaffected (wild type) kidneys. Renal immune cells are conserved among species although their proportion is different, even when comparing rat versus mouse. It is possible that these differences in immune cell proportions partially explain why altering immune cell function via genetic loss or pharmacologic intervention has a differing effect on PKD pathogenesis in mouse versus rat models.