Table 1.
Involvement of immune cell types in PKD
| Cell type | Reported in mouse models of cystic disease | Reported in human PKD patients | Functional role in cystic kidney disease pathogenesis |
|---|---|---|---|
| Innate lymphoid cells (ILCs) | No | No | Unknown |
| Natural killer cells | No | No | Unknown |
| Eosinophils | No | No | Unknown |
| Basophils | No | No | Unknown |
| Dendritic cells (cDC1 and cDC2) | No | No | Unknown |
| Mast cells | No | Yes | Unknown |
| Neutrophils | Yes | Yes | Unknown |
| Non-specified macrophages | Yes | Yes | Yes |
| Infiltrating macrophages | Yes | Yes | Yes |
| Resident macrophages | Yes | No | Yes |
| B cells | Yes | Yes | Unknown |
| CD8 T cells | Yes | Yes | Yes |
| CD4 T cells | Yes | Yes | Unknown |
| DN T cells | Yes | Yes | Unknown |
| NK T cells | No | No | Unknown |
| ɣδ T cells | No | No | Unknown |