Table 1.

Causes of post-transplant thrombotic microangiopathy.

1. Caused by complement protein mutations: atypical hemolytic uremic syndrome

2. De novo post-transplant associated TMA or secondary aHUS     a. Related to the type of donor and the organ procurement         - Complement activation associated to DBD and CDC         - Ischemia reperfusion injury     b. Associated to post-transplant events      - Drugs         - Calcineurin inhibitors         - mTOR inhibitors      - ABMR      - Infection      - Viral: CMV, parvovirus, Nile fever      - Funghi       Antiphospholipid syndrome     c. Other causes of TMA not related to the kidney transplant: malignancies, pregnancy, other drugs (anti VEGF, gemcitabine,…)

DBD, donor after brain death; DCD, donor after cardiocirculatory death; ABMR, antibody mediated rejection; CMV, cytomegalovirus.