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. 2021 Apr 9;11:584884. doi: 10.3389/fonc.2021.584884

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Copyright © 2021 Cheng, Wang, Qi, Liu, Wang, Wan, Liu, Su, Jin, Liu, Li, Sang, Yang, Liu, Duan and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of the survival model to screen hub prognostic mRNAs. (A) Forest map of univariate Cox proportional hazards regression: 16 mRNAs with P < 0.05 were screened out of 43 common mRNAs (marked by *). (B, C) Lasso regression screening of mRNAs into multivariate Cox regression: λ and cv graphs show that eight hub mRNAs were selected. (D) Forest map of multivariate Cox proportional hazards regression: three hub prognostic mRNAs (KCNK10, EPB41L3, COL2A1) were screened out. (E) ROC curve of multivariate Cox regression: AUC of 5-year survival was 0.777, indicating the high accuracy of multivariate Cox regression model. (F) The AML samples were divided into high and low risk groups according to the risk scores obtained from Cox regression. (G) Survival curve of high and low risk groups: the survival rate of the high-risk group was significantly reduced (P = 0.0011). (H) Heatmap of KCNK10, EPB41L3, and COL2A1 expressions among the high and low risk group samples. (I) Nomogram of KCNK10, EPB41L3, and COL2A1 based on the results of the multivariate Cox regression.