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. 2021 Apr 9;11:584884. doi: 10.3389/fonc.2021.584884

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Copyright © 2021 Cheng, Wang, Qi, Liu, Wang, Wan, Liu, Su, Jin, Liu, Li, Sang, Yang, Liu, Duan and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Verifying the prognostic value of the three core mRNAs. (A–C) Survival curve of the three hub mRNAs: the survival rate of AML patients with high expression of EPB41L3 significantly decreased (P = 0.011), and the survival rate of AML patients with low expression of COL2A1 significantly decreased (P = 0.013). There is no significant difference in survival rate between different KCNK10 expression levels (P = 0.681), so we believe that EPB41L3 and COL2A1 are core prognostic mRNAs with predictive value. (D) Nomogram of EPB41L3 and COL2A1 based on the results of the multivariate Cox regression. (E) Hub prognostic ceRNA network based on EPB41L3 and COL2A1; (F) Forest map of multivariate Cox regression analysis: the risk score of prognostic model maintained independence in predicting the OS of AML patients (HR = 1.8469, 95% CI = 1.2652–2.6961, P = 0.00147). At the same time, age and cytogenetic risk groups of AML patients also have independent prognosis value. (G) The nomogram of the risk score of prognostic model and clinic characters.