Table 2.
Genomic alterations of 25 bronchiolar adenomas from 21 patients
| Patient-Tumor | Morphology | Methodology | Number of genes tested | Putative Driver Mutation | Secondary Mutations | BRAF IHC | Driver in concurrent adenocarcinoma |
|---|---|---|---|---|---|---|---|
| 1 | Proximal | Ampliseq | 98 | BRAF p.V600E (COSM476) | Positive | KRAS p.G12C | |
| 2 | Proximal | ARMS | 9 | Not detected | ND | ||
| 3 | Proximal | Ampliseq | 98 | Not detected | Negative | ||
| 4 | Proximal | Ampliseq | 98 | Not detected | Negative | ||
| 5 | Proximal | Ampliseq | 98 | EGFR ex20 p.D773_N774insNPH (COSM12381)* | Negative | ||
| 6 | Proximal | Ampliseq | 98 | KRAS p.G12D (COSM521) | Negative | ||
| 7 | Proximal | Ampliseq | 50 | KRAS p.G12V (COSM520) | Negative | ||
| 8–1 | Proximal | Ampliseq | 98 | EGFR ex19 p.E746_S752>V (COSM12384) | Negative | ||
| 8–2 | Distal | Ampliseq | 98 | BRAF p.V600E (COSM476) | Positive | ||
| 8–3 | Distal | Ampliseq | N/A | Failed (low tumor) | Negative | ||
| 9–1 | Distal | MSK-IMPACT | 410 | BRAF p.V600E (COSM476) | Positive | KRAS p.G12C | |
| 9–2 | Distal | MSK-IMPACT | 410 | BRAF p.V600E (COSM476) | Positive | ||
| 10–1 | Distal | Ampliseq | 98 | HRAS p.G13R (COSM486) | BRAF p.G464V (COSM450) | Negative | |
| 10–2 | Distal | Ampliseq | 98 | BRAF p.V600E (COSM476) | Positive | ||
| 11 | Distal | MSK-IMPACT | 410 | BRAF p.V600E (COSM476) | Positive | KRAS p.G12D | |
| 12 | Distal | IHC only | N/A | BRAF p.V600E (COSM476) | Positive | EGFR p.E746_A750del | |
| 13 | Distal | IHC only | N/A | BRAF p.V600E (COSM476) | Positive | ||
| 14 | Distal | Ampliseq | 98 | EGFR ex20 p.D773_N774insNPH (COSM12381)* | Negative | ||
| 15 | Distal | Ampliseq | 6 | EGFR ex19 p.L747_S752del (COSM6255) | EGFR ex19 p.D761Y (COSM21984) | ND | |
| 16 | Distal | Ampliseq | 98 | KRAS p.G12C (COSM516) | U2AF1 p.S34F (COSM166866) | Negative | KRAS p.G12A |
| 17 | Distal | Ampliseq | 98 | KRAS p.G12V (COSM520) | U2AF1 p.S34F (COSM166866) | Negative | |
| 18 | Distal | Ampliseq | 98 | KRAS p.G12D (COSM521) | U2AF1 p.S34F (COSM166866) | Negative | |
| 19 | Distal | MSK-IMPACT | N/A | Failed (low tumor) | ND | ||
| 20 | Distal | ND | N/A | ND | Negative | ||
| 21 | Distal | ND | N/A | ND | Negative |
*
Alternative annotation: N771_H773dup