Table 3.
Differences in immunophenotypes between conventional grade III and HGT ACC.
| Antibodies | n | Conventional grade III | HGT | P-value |
|---|---|---|---|---|
| Calponin | 0.008 | |||
| Neg/f Pos | 12 (46.2) | 2 (16.7) | 10 (71.4) | |
| Pos | 14 (53.8) | 10 (83.3) | 4 (28.6) | |
| p63 | <0.001 | |||
| Neg/f Pos | 13 (50) | 0 (0) | 13 (92.9) | |
| Pos | 13 (50) | 12 (100) | 1 (7.1) | |
| CK7 | – | |||
| Neg/f Pos | 0 (0) | 0 (0) | 0 (0) | |
| Pos | 26 (100) | 12 (100) | 14 (100) | |
| CK5/6 | 0.483 | |||
| Neg/f Pos | 2 (7.7) | 0 (0) | 2 (14.3) | |
| Pos | 24 (92.3) | 12 (100) | 12 (85.7) | |
| S100 | 0.683 | |||
| Neg/f Pos | 9 (34.6) | 5 (41.7) | 4 (28.6) | |
| Pos | 17 (65.4) | 7 (58.3) | 10 (71.4) | |
| p53 | 0.100 | |||
| Scattered | 22 (84.6) | 12 (100) | 10 (71.4) | |
| Aberrant | 4 (5.4) | 0 (0) | 4 (28.6) | |
| Ki-67 | 0.005 | |||
| ≤20% | 16 (61.5) | 11 (91.7) | 5 (35.7) | |
| >20% | 10 (38.5) | 1 (8.3) | 9 (64.3) |
HGT, high-grade transformation; ACC, adenoid cystic carcinoma; Neg, negative; f, focal; Pos, positive.