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. 2021 Apr 9;11:647172. doi: 10.3389/fonc.2021.647172

Table 4.

Correlation between tumor grading and clinicopathological characteristics.

Characteristics n Grade I–II Conventional grade III HGT P-value
Gender 0.15
 Male 33 (45.2) 21 (44.7) 8 (66.7) 4 (28.6)
 Female 40 (54.8) 26 (55.3) 4 (33.3) 10 (71.4)
Age groups 0.566
 ≤50y 37 (50.7) 26 (55.3) 5 (41.7) 6 (42.9)
 >50y 36 (49.3) 21 (44.7) 7 (58.3) 8 (57.1)
Primary sites 0.641
 Major salivary 17 (23.3) 7 (14.9) 4 (33.3) 6 (42.9)
 Nasal cavity and paranasal sinuses 15 (20.5) 10 (21.3) 2 (16.7) 3 (21.4)
 lip and oral cavity 15 (20.5) 10 (21.3) 2 (16.7) 3 (21.4)
 Trachea 9 (12.3) 7 (14.9) 2 (16.7) 0 (0)
 Pharynx 7 (9.6) 6 (12.8) 1 (8.3) 0 (0)
 External auditory canal 5 (6.8) 3 (6.4) 1 (8.3) 1 (7.1)
 Larynx 3 (4.1) 3 (6.4) 0 (0) 0 (0)
 Lacrimal gland 2 (2.7) 1 (2.1) 0 (0) 1 (7.1)
PNI 0.169
 Negative 12 (16.4) 10 (21.3) 2 (16.7) 0 (0)
 Positive 61 (83.6) 37 (78.7) 10 (83.3) 14 (100)
Margin status 0.422
 ≥1 mm 11 (15.1) 9 (19.1) 1 (8.3) 1 (7.1)
 <1 mm 62 (84.9) 38 (80.9) 11 (91.7) 13 (92.9)
T stage 0.127
 1–2 20 (27.4) 14 (29.8) 4 (33.3) 2 (14.3)
 3 34 (46.6) 25 (53.2) 4 (33.3) 5 (35.7)
 4 19 (26) 8 (17) 4 (33.3) 7 (50)
LNM (n = 34) 0.009
 Negative 25 (73.5) 20 (87) 3 (75) 2 (28.6)
 Positive 9 (26.5) 3 (13) 1 (25) 5 (71.4)
Stage groups 0.039
 I–II 19 (26) 14 (29.8) 4 (33.3) 1 (7.1)
 III 31 (42.5) 23 (48.9) 4 (33.3) 4 (28.6)
 IV 23 (31.5) 10 (21.3) 4 (33.3) 9 (64.3)
PORT (n = 68) 0.664
 Yes 39 (57.4) 27 (61.4) 6 (50) 6 (50)
 No 29 (42.6) 17 (38.6) 6 (50) 6 (50)

HGT, high-grade transformation; PNI, perineural invasion; LNM, lymph node metastasis; PORT, postoperative radiotherapy.