Table 6.
Multivariate Cox regression analysis.
| Characteristics | PFS | OS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Age groups | 0.008 | – | ||||
| ≤50y (reference) | 1 | – | – | |||
| >50y | 0.321 | 0.138–0.747 | – | – | ||
| PNI | 0.066 | – | ||||
| Negative (reference) | 1 | – | – | |||
| Positive | 6.698 | 0.88–51.002 | – | – | ||
| Tumor grading | <0.001 | 0.001 | ||||
| Grade I–II (reference) | 1 | 1 | ||||
| Conventional Grade III | 5.035 | 1.979–12.814 | 0.001 | 1.77 | 0.318–9.849 | 0.514 |
| HGT | 9.616 | 3.222–28.697 | <0.001 | 10.728 | 2.998–38.393 | <0.001 |
| PORT | 0.002 | 0.024 | ||||
| Yes (reference) | 1 | 1 | ||||
| No | 3.895 | 1.636–9.273 | 4.336 | 1.214–15.489 | ||
PFS, progression-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval; HGT, high-grade transformation; PORT, postoperative radiotherapy.