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. 2021 Mar 24;10(4):253. doi: 10.3390/biology10040253

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme of the telomerase complex, consisting of two main subunits: telomerase RNA (TERC) that contains the RNA template region, and telomerase catalytic subunit (TERT), which is responsible for adding the new segment. Adrenocortical dysplasia protein homolog (TPP1) acts as a telomerase recruiter. In addition, the accessory proteins for the enzyme to be fully functional are shown: Dyskerin, H/ACA ribonucleoprotein complex subunit 1 (GAR1), telomerase Cajal body protein 1 (TCAB1), H/ACA ribonucleoprotein complex subunit 2 (NHP2), and and H/ACA ribonucleoprotein subunit 3 (NOP10). The pontin and reptin proteins are in charge of its remodeling and assembly.