Table 2.

Adverse events after PD-1, PD-L1 blockade.

Affected Organ/System	Adverse Event	Symptoms	References
Lung	Pneumonitis	asymptomatic, cough, dyspnea, chest pain, wheezing	[132,133]
	Sarcoidosis	asymptomatic, cough, dyspnea
Gastrointestinal	Colitis	diarrhea, bloody stools, abdominal discomfort or pain,	[132,134]
	Esophagitis	anorexia, nausea loss of appetite, abdominal pain, nausea, vomiting
	Gastritis
	Mucositis
	Pancreatitis	Fever, nausea, vomiting, abdominal pain with irradiation in the back	[135]
Liver	Hepatitis	asymptomatic, fever, nausea, vomiting	[134]
Skin	Skin Rash		[136]
	Pruritus
	Vitiligo
Endocrine	Hypophysitis	fatigue, headache, nausea, postural hypotension, anorexia, tachycardia	[132,134]
	Hypothyroidism	asymptomatic, fatigue, constipation, bradycardia, cold intolerance	[132,137]
	Hypertiroidism	tachycardia, tremor
	Diabetes mellitus type I	Asymptomatic, polyuria, polydipsia	[132,137]
Ocular	Uveitis	eye redness and pain, decreased vision	[138]
Neurologic	Meningitis, encephalitis, Guillain Barre syndrome, myastenia gravis, polyradiculitis,	nausea, fatigue, headache, blurred vision, dysesthesia, fever, hallucinations, confusion, muscle weakness, tetraplegia, paraplegia	[139]
Cardiac	Myocarditis, pericarditis hypertension, arrhythmias, myocardial infarction	palpitations, dyspnea, chest pain, fatigue	[134,140]
Hematological	Aplastic anemia, hemolytic anemia, immune thrombocytopenia	fatigue, bleeding, infections	[132]
Rheumatologic	Vasculitis, Sicca syndrome, polymiositis, systemic lupus erythematosus	mialgia, joint swelling and pain, dryness of mouth and eye	[141]