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. 2021 Apr 20;9:e11272. doi: 10.7717/peerj.11272

Table 2. GO and KEGG analysis of differentially expressed DEG associated with CCRCC.

Expression Category Term Count P-value
Upregulated GO_BP GO:0006954∼inflammatory response 30 1.30E−12
GO_BP GO:0007165∼signal transduction 29 1.31E−02
GO_BP GO:0007155∼cell adhesion 26 5.33E−08
GO_BP GO:0006955∼immune response 24 1.76E−07
GO_BP GO:0042493∼response to drug 21 5.92E−08
GO_BP GO:0045087∼innate immune response 19 1.36E−04
GO_BP GO:0030198∼extracellular matrix organization 18 1.08E−08
GO_BP GO:0050900∼leukocyte migration 17 6.55E−11
GO_BP GO:0001525∼angiogenesis 17 4.06E−07
GO_BP GO:0008284∼positive regulation of cell proliferation 17 2.57E−03
GO_CC GO:0005886∼plasma membrane 108 1.13E−09
GO_CC GO:0016021∼integral component of membrane 107 2.03E−04
GO_CC GO:0070062∼extracellular exosome 66 2.68E−04
GO_CC GO:0016020∼membrane 64 4.11E−07
GO_CC GO:0005887∼integral component of plasma membrane 62 6.07E−14
GO_CC GO:0005576∼extracellular region 50 1.98E−06
GO_CC GO:0005615∼extracellular space 49 2.48E−08
GO_CC GO:0009986∼cell surface 31 1.08E−09
GO_CC GO:0005783∼endoplasmic reticulum 20 4.86E−02
GO_CC GO:0000139∼Golgi membrane 17 1.94E−02
GO_MF GO:0005515∼protein binding 154 6.05E−03
GO_MF GO:0005524∼ATP binding 36 6.15E−03
GO_MF GO:0042803∼protein homodimerization activity 21 7.66E−03
GO_MF GO:0042802∼identical protein binding 20 1.92E−02
GO_MF GO:0005102∼receptor binding 19 7.41E−06
GO_MF GO:0004872∼receptor activity 14 2.70E−05
GO_MF GO:0004672∼protein kinase activity 12 2.09E−02
GO_MF GO:0005215∼transporter activity 8 3.41E−02
GO_MF GO:0004888∼transmembrane signaling receptor activity 8 4.43E−02
GO_MF GO:0005201∼extracellular matrix structural constituent 7 5.17E−04
KEGG hsa04151: PI3K-Akt signaling pathway 19 2.01E−04
KEGG hsa04510: Focal adhesion 17 3.76E−06
KEGG hsa05200: Pathways in cancer 17 5.96E−03
KEGG hsa04066: HIF-1 signaling pathway 12 3.37E−06
KEGG hsa04015: Rap1 signaling pathway 12 3.56E−03
KEGG hsa04145: Phagosome 10 3.39E−03
KEGG hsa05205: Proteoglycans in cancer 10 2.05E−02
KEGG hsa05150: Staphylococcus aureus infection 9 1.14E−05
KEGG hsa04611: Platelet activation 9 4.86E−03
KEGG hsa05133: Pertussis 8 7.79E−04
Downregulated GO_BP GO:0055114∼oxidation–reduction process 33 3.33E−05
GO_BP GO:0034220∼ion transmembrane transport 19 5.29E−06
GO_BP GO:0042493∼response to drug 18 1.62E−03
GO_BP GO:0006811∼ion transport 14 1.66E−05
GO_BP GO:0055085∼transmembrane transport 14 8.16E−03
GO_BP GO:0007588∼excretion 13 4.97E−11
GO_BP GO:0010628∼positive regulation of gene expression 13 3.13E−02
GO_BP GO:0006814∼sodium ion transport 12 4.94E−06
GO_BP GO:0001822∼kidney development 12 8.92E−06
GO_BP GO:0008152∼metabolic process 12 3.22E−03
GO_CC GO:0016021∼integral component of membrane 171 4.63E−07
GO_CC GO:0070062∼extracellular exosome 170 1.01E−33
GO_CC GO:0005886∼plasma membrane 162 2.99E−12
GO_CC GO:0005887∼integral component of plasma membrane 76 3.16E−11
GO_CC GO:0005615∼extracellular space 50 1.87E−03
GO_CC GO:0016324∼apical plasma membrane 44 4.39E−22
GO_CC GO:0016323∼basolateral plasma membrane 28 2.05E−14
GO_CC GO:0009986∼cell surface 24 5.53E−03
GO_CC GO:0005759∼mitochondrial matrix 19 8.74E−04
GO_CC GO:0043025∼neuronal cell body 15 1.88E−02
GO_MF GO:0042803∼protein homodimerization activity 33 7.43E−04
GO_MF GO:0005509∼calcium ion binding 29 7.77E−03
GO_MF GO:0043565∼sequence-specific DNA binding 20 4.43E−02
GO_MF GO:0016491∼oxidoreductase activity 13 3.24E−03
GO_MF GO:0046983∼protein dimerization activity 11 3.31E−03
GO_MF GO:0008201∼heparin binding 11 5.22E−03
GO_MF GO:0005088∼Ras guanyl-nucleotide exchange factor activity 10 1.78E−03
GO_MF GO:0003824∼catalytic activity 10 3.74E−02
GO_MF GO:0016787∼hydrolase activity 10 4.07E−02
GO_MF GO:0046934∼phosphatidylinositol-4,5-bisphosphate 3-kinase activity 9 1.10E−04
KEGG hsa01100: Metabolic pathways 68 8.56E−08
KEGG hsa01130: Biosynthesis of antibiotics 19 5.17E−05
KEGG hsa01200: Carbon metabolism 11 1.83E−03
KEGG hsa04960: Aldosterone-regulated sodium reabsorption 9 1.45E−05
KEGG hsa04978: Mineral absorption 9 3.69E−05
KEGG hsa00010: Glycolysis / Gluconeogenesis 9 7.57E−04
KEGG hsa04610: Complement and coagulation cascades 8 4.14E−03
KEGG hsa04966: Collecting duct acid secretion 7 1.11E−04
KEGG hsa00260: Glycine, serine and threonine metabolism 7 9.10E−04
KEGG hsa00280: Valine, leucine and isoleucine degradation 7 2.46E−03