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. Author manuscript; available in PMC: 2022 Mar 11.
Published in final edited form as: J Med Chem. 2021 Feb 12;64(5):2691–2704. doi: 10.1021/acs.jmedchem.0c01922

Figure 2:

Figure 2:

Overlaid Inhibition curves for TO-317 against a panel of 11 Zn2+-based HDAC homologs. TO-317 shows in vitro HDAC6 selectivity across all Zn2+-dependent HDAC homologs and becomes a viable candidate for further biological investigation of the HDAC6 enzyme.