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Docking conformation of TO-317 with drHDAC6 CD2 (PDB 5WGI) reveals occupancy of both L1 and L2 crevices which facilitates a plethora of interactions. Deck A shows the pocket view of these interactions, while deck B shows how TO-317 adopts a windmill conformation that allows both aromatic ring cap groups to engage with the L1 and L2 crevices of the HDAC6 outer surface.
