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. Author manuscript; available in PMC: 2022 Mar 11.
Published in final edited form as: J Med Chem. 2021 Feb 12;64(5):2691–2704. doi: 10.1021/acs.jmedchem.0c01922

Figure 4.

Figure 4.

Stereo-view of a Polder omit map (contoured at 4.0σ) showing the binding of TO-317 in the active site of HDAC6 (PDB code: 7JOM). The catalytic Zn2+ ion is shown as a grey sphere, the Zn2+ bound water molecule is shown as a red sphere; metal coordination and hydrogen bond interactions are shown as solid and dashed black lines, respectively.