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TO-317 showed extended lifetimes in both mouse plasma and pooled human blood stability assays. Assay values reported was an average of triplicate studies.
| Remaining Percentage TO-317 Concentration | |||||
|---|---|---|---|---|---|
| Assay | 0 min | 15 min | 30 min | 60 min | T1/2 (min) |
| Mouse Plasma* | 100% | 88.1% | 79.8.0% | 68.0% | 110 |
| Human Whole Blood* | 100% | 88.0% | 80.8% | 68.9% | 108 |
