Table 1.
Expression levels of the antigens TRP2, ABCB5, P53, gp100, and GD2 in correlation with clinical parameters as age, gender, tumor stage, tumor thickness, ulceration of the primary tumor, BRAF V600E/K status, serological LDH and S100 levels.
| All (n = 168) | TRP2 (n = 141) | ABCB5 (n = 137) | P53 (n = 139) | gp100 (n = 138) | GD2 (n = 139) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| (n) | Low (n) | High (n) | Low (n) | High (n) | Low (n) | High (n) | Low (n) | High (n) | Low (n) | High (n) | |
| Age | |||||||||||
| <67 | 44% (74) | 21% (30) | 23% (33) | 37% (50) | 9% (12) | 29% (40) | 16% (22) | 20% (17) | 25% (34) | 26% (36) | 19% (27) |
| >67 | 56% (94) | 28% (40) | 27% (38) | 47% (64) | 8% (11) | 34% (47) | 22% (30) | 20% (17) | 36% (50) | 37% (51) | 18% (25) |
| Gender | |||||||||||
| Male | 58% (98) | 28% (40) | 29% (41) | 49% (67) | 9% (12) | 33% (46) | 24% (33) | 23% (31) | 35% (48) | 36% (50) | 21% (29) |
| Female | 42% (70) | 21% (30) | 21% (30) | 34% (47) | 8% (11) | 30% (41) | 14% (19) | 17% (23) | 26% (36) | 27% (37) | 17% (23) |
| Tumor Stage | |||||||||||
| I + II | 58% (98) | 21% (30) | 33% (47) | 43% (59) | 11% (15) | 35% (49) | 19% (26) | 20% (27) | 35% (48) | 34% (47) | 21% (29) |
| III + IV | 42% (70) | 28% (40) | 17% (24) | 40% (55) | 6% (8) | 27% (38) | 19% (26) | 20% (27) | 26% (36) | 29% (40) | 17% (23) |
| Tumor Thickness | |||||||||||
| <1.5 mm | 46% (77) | 16% (23) | 29% (41) | 33% (45) | 12% (16) | 31% (43) | 14% (19) | 18% (25) | 28% (38) | 27% (38) | 19% (26) |
| >1.5 mm | 47% (79) | 27% (38) | 20% (28) | 42% (58) | 5% (7) | 27% (38) | 20% (28) | 16% (22) | 30% (42) | 30% (41) | 17% (23) |
| missing | 7% (12) | 6% (9) | 1% (2) | 8% (11) | 0% (0) | 4% (6) | 4% (5) | 5% (7) | 3% (4) | 6% (8) | 2% (3) |
| Ulceration | |||||||||||
| yes | 29% (49) | 16% (22) | 14% (19) | 25% (34) | 4% (6) | 16% (22) | 14% (19) | 8% (11) | 21% (29) | 16% (22) | 22% (30) |
| no | 62% (104) | 26% (37) | 35% (49) | 48% (66) | 12% (17) | 42% (58) | 19% (26) | 25% (34) | 36% (50) | 40% (55) | 13% (18) |
| missing | 9% (15) | 8% (11) | 2% (3) | 10% (14) | 0% (0) | 5% (7) | 5% (7) | 7% (9) | 4% (5) | 7% (10) | 3% (4) |
| BRAF V600 E/K | |||||||||||
| yes | 17% (28) | 12% (17) | 6% (9) | 15% (21) | 3% (4) | 12% (16) | 7% (10) | 9% (13) | 9% (13) | 12% (17) | 9% (13) |
| no | 25% (43) | 14% (20) | 13% (18) | 25% (34) | 3% (4) | 15% (21) | 12% (17) | 11% (15) | 16% (22) | 17% (23) | 7% (9) |
| missing | 58% (97) | 23% (33) | 31% (44) | 43% (59) | 11% (15) | 36% (50) | 18% (25) | 19% (26) | 36% (49) | 34% (47) | 22% (30) |
| LDH | |||||||||||
| normal | 70% (117) | 38% (53) | 32% (45) | 58% (79) | 13% (18) | 42% (59) | 27% (37) | 28% (38) | 42% (58) | 45% (62) | 25% (34) |
| elevated | 14% (24) | 9% (12) | 6% (9) | 12% (17) | 2% (3) | 9% (13) | 6% (8) | 6% (8) | 9% (12) | 9% (13) | 6% (8) |
| missing | 16% (27) | 4% (5) | 12% (17) | 12% (17) | 2% (3) | 11% (15) | 5% (7) | 6% (8) | 10% (14) | 9% (12) | 7% (10) |
| S100 | |||||||||||
| normal | 74% (125) | 33% (47) | 41% (58) | 61% (84) | 13% (18) | 48% (66) | 28% (39) | 29% (40) | 46% (64) | 45% (63) | 29% (40) |
| elevated | 20% (34) | 13% (18) | 9% (12) | 20% (27) | 2% (2) | 12% (17) | 9% (12) | 8% (11) | 12% (17) | 15% (21) | 7% (9) |
| missing | 6% (9) | 4% (5) | 1% (1) | 2% (3) | 2% (3) | 3% (4) | 1 (1%) | 2% (3) | 2% (3) | 2% (3) | 2% (3) |