Figure 3.
Effects of repetitive angiotensin II (Ang II) infusion on coronary flow (A), left ventricular developed pressure (LVDevP) (B), +dLVP/dtmax (C) and −dLVP/dtmax (D) of isolated rat hearts. Maximal decrease in coronary flow during repetitive infusion periods (E). Decrease in LVDevP when the coronary flow is reduced either mechanically by compressing the perfusion line (grey) or by the vasoactive effect of Ang II (green) (F). Ang II (10−7 M) was administered repetitively to the perfusate of isolated rat hearts (A–E). Each Ang II infusion period lasted for 3 min and was followed by a 10-min wash-out period. Mean ± SEM; n = 4; * p < 0.05 vs. control (pre-infusion value) in each group; one-way repeated measurement ANOVA and Dunnett’s post-hoc test; # p < 0.05 vs. first infusion period; one-way ANOVA and Dunnett’s post-hoc test; $ p < 0.05 vs. relative decrease in coronary flow, paired t-test.