Figure 4.

Peak effects of 2-arachydonoyl-glycerol (2-AG) and synthetic CB receptor agonist WIN55,212-2 on coronary flow (A) and left ventricular developed pressure (LVDevP) (B) of isolated rat hearts. 2-AG (10⁻⁶ M) and WIN55,212-2 (10⁻⁶ M) were administered to the perfusate for 5 min. After a 10-min wash-out period, the 2-AG infusion was repeated in the presence of CB₁R antagonist O2050 (10⁻⁶ M). Data are presented as relative values compared to pre-infusion control data. Mean ± SEM; n = 9 (2-AG and 2-AG + O2050 experiments) and n = 5 (WIN55,212-2 experiments); * p < 0.05 vs. pre-infusion value; # p < 0.05 vs. 2-AG peak effect, paired t-test.