Table 5. Linear relationship between vitamin D metabolites and MRI in ASPS-Fam.
| ASPS-Fam | 25(OH)D [nmol/L] | 24,25(OH)2D3 [nmol/L] | VMR [%] | ||||||
| N = 139 | β | SE | p | β | SE | p | β | SE | p |
| Total Gray Matter Volume | -5.84E-05 | 5.70E-05 | 0.31 | 4.06E-05 | 8.78E-04 | 0.96 | 1.04E-03 | 9.69E-04 | 0.28 |
| Subcortical Gray Matter Volume | -1.18E-05 | 7.03E-06 | 0.09 | -1.49E-04 | 1.08E-04 | 0.17 | -1.27E-04 | 1.22E-04 | 0.30 |
| Hippocampus Volume | -1.24E-07 | 7.96E-07 | 0.88 | -9.94E-07 | 1.22E-05 | 0.94 | -3.30E-06 | 1.34E-05 | 0.81 |
| Cortical Volume | |||||||||
| Total | -3.00E-05 | 4.54E-05 | 0.51 | 2.52E-04 | 6.97E-04 | 0.72 | 1.03E-03 | 7.64E-04 | 0.18 |
| Frontal Lobe | -1.38E-05 | 1.91E-05 | 0.47 | 4.04E-05 | 2.94E-04 | 0.89 | 3.86E-04 | 3.23E-04 | 0.23 |
| Temporal Lobe | 1.75E-06 | 1.05E-05 | 0.87 | 1.59E-04 | 1.61E-04 | 0.32 | 2.40E-04 | 1.80E-04 | 0.18 |
| Parietal Lobe | -1.28E-05 | 1.31E-05 | 0.33 | 1.02E-05 | 2.01E-04 | 0.96 | 2.31E-04 | 2.21E-04 | 0.30 |
| Occipital Lobe | -3.08E-06 | 6.28E-06 | 0.62 | 3.70E-05 | 9.64E-05 | 0.70 | 9.33E-05 | 1.08E-04 | 0.39 |
| Cortical Thickness | |||||||||
| Frontal Lobe | -9.95E-07 | 3.73E-06 | 0.79 | -1.96E-05 | 5.74E-05 | 0.73 | -3.80E-05 | 6.45E-05 | 0.56 |
| Temporal Lobe | 1.28E-06 | 3.45E-06 | 0.71 | 4.42E-05 | 5.29E-05 | 0.40 | 1.97E-05 | 5.91E-05 | 0.74 |
| Parietal Lobe | -1.78E-06 | 3.43E-06 | 0.60 | -1.48E-05 | 5.27E-05 | 0.78 | -4.16E-06 | 5.85E-05 | 0.94 |
| Occipital Lobe | -2.92E-06 | 2.65E-06 | 0.27 | -2.44E-05 | 4.08E-05 | 0.55 | -7.66E-06 | 4.53E-05 | 0.87 |
| Cortical Surface Area | |||||||||
| Frontal Lobe | -3.44E-04 | 7.14E-04 | 0.63 | 5.06E-03 | 1.10E-02 | 0.65 | 2.01E-02 | 1.23E-02 | 0.10 |
| Temporal Lobe | -1.43E-04 | 3.76E-04 | 0.70 | -4.65E-04 | 5.77E-03 | 0.94 | 4.40E-03 | 6.46E-03 | 0.50 |
| Parietal Lobe | -2.30E-04 | 5.24E-04 | 0.66 | 2.41E-03 | 8.05E-03 | 0.76 | 9.41E-03 | 9.03E-03 | 0.30 |
| Occipital Lobe | 2.37E-04 | 3.03E-04 | 0.43 | 4.55E-03 | 4.65E-03 | 0.33 | 3.66E-03 | 5.24E-03 | 0.49 |
ASPS-Fam: Austrian Stroke Prevention Family Study, N: number of individuals in analyses, VMR: vitamin D metabolite ratio, β: regression coefficient, SE: standard error of regression coefficient, p: p-value.
All analyses are adjusted for age, sex, hypertension, diabetes, atrial fibrillation, season at blood draw and family structure. All Freesurfer variables are normalized for total intracranial volume.