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. 2021 Mar 19;13(7):9646–9664. doi: 10.18632/aging.202708

Figure 2.

Figure 2

Deletion of BMP5 attenuates osteoarthritis in the in vivo DMM model mice. (A) Representative images show hematoxylin and eosin (H&E) staining, toluidine staining and Safranin O-Fast Green staining of knee cartilage tissue sections from LV-siBMP5 and LV-siNC group mice (n=5 per group). (B) RT-PCR results show BMP5 mRNA levels in LV-siBMP5 and LV-siNC group mice at 2 weeks post-DMM surgery (n = 5 per group). (C) Representative images show synovitis and SBP thickness in the sham-operated, DMM plus LV-siNC, and DMM plus LV-siBMP5 groups of mice at 4 weeks post-DMM operation. (D) OARSI scores and hyaline cartilage/calcified cartilage ratios in sham-operated, DMM plus LV-siNC, and DMM plus LV-siBMP5 groups of mice at 4 weeks post-DMM operation. (E) Quantitative analysis shows the status of synovitis and SBP thickness in the sham-operated, DMM plus LV-siNC, and DMM plus LV-siBMP5 groups of mice at 4 weeks post-DMM operation. All data are represented as the means ± SD (n=5 per group); scale bars: 5 μm.