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The sketch map of the regulatory loop of the miR-224-SIRT3-AMPK-mTOR-HIF-1α axis. miR-224 targeted SIRT3 and inhibited AMPK, followed by up-regulation of mTOR-HIF-1α. A higher level of HIF-1α then enhanced the transcription of miR-224 as well as the other genes in promoting cell growth, angiogenesis and metastasis of NSCLC cells.
