Table 4. Significantly enriched immune relevant GO terms in old females and males at Day 180.

Contrast	Sex	GO ID	Description	Category	Genes‡	padj
D180 vs. D0	Female	GO:0045047	protein targeting to ER	BP	14	5.77E-18
		GO:0006364	rRNA processing	BP	16	1.19E-14
		GO:0042788	polysomal ribosome	CC	6	5.31E-08
		GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	CC	4	3.08E-06
		GO:0005924	cell-substrate adherent junction	CC	6	0.049794522
		GO:0003735	structural constituent of ribosome	MF	14	3.19E-13
	Male	GO:0006612	protein targeting to membrane	BP	82	7.94E-39
		GO:0006119	oxidative phosphorylation	BP	58	9.48E-27
		GO:0043624	cellular protein complex disassembly	BP	54	4.69E-13
		GO:0010257	NADH dehydrogenase complex assembly	BP	27	1.93E-11
		GO:0032981	mitochondrial respiratory chain complex I assembly	BP	27	1.93E-11
		GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	BP	22	2.36E-06
		GO:0006521	regulation of cellular amino acid metabolic process	BP	17	7.53E-05
		GO:0010499	proteasomal ubiquitin-independent protein catabolic process	BP	9	0.002674681
		GO:1903321	negative regulation of protein modification by small protein conjugation or removal	BP	17	0.002681796
		GO:0006959	humoral immune response	BP	29	0.005762827
		GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	BP	17	0.006188976
		GO:0045116	protein neddylation	BP	6	0.031860865
		GO:0050852	T cell receptor signaling pathway	BP	29	0.036706782
		GO:2001242	regulation of intrinsic apoptotic signaling pathway	BP	24	0.043430667
		GO:0000502	proteasome complex	CC	18	5.02E-05
D180 vs. D28	Female	GO:0002763	positive regulation of myeloid leukocyte differentiation	BP	1	0.017610107
		GO:0038095	Fc-epsilon receptor signaling pathway	BP	1	0.020494521
		GO:0001047	core promoter binding	MF	1	0.016815814
	Male	GO:0045047	protein targeting to ER	BP	65	5.57E-55
		GO:0006119	oxidative phosphorylation	BP	49	5.97E-28
		GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	BP	13	0.003315273
		GO:0031640	killing of cells of other organism	BP	9	0.006461521
		GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	BP	10	0.01646663
		GO:1902750	negative regulation of cell cycle G2/M phase transition	BP	14	0.032386761
		GO:0097526	spliceosomal tri-snRNP complex	CC	9	0.00013242
		GO:0005839	proteasome core complex	CC	5	0.030643822
		GO:0003735	structural constituent of ribosome	MF	94	1.90E-78
		GO:0140104	molecular carrier activity	MF	8	0.020074571
		GO:0004298	threonine-type endopeptidase activity	MF	5	0.048464518

Note: ‘‡’ indicated the number of genes enriched in the GO terms.