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. 2021 Apr 4;13(7):10369–10386. doi: 10.18632/aging.202798

Table 2. Significant SNPs (P-values < 0.05) from a Kruskal-Wallis test for the association with ESCC (N=969).

SNP Position Gene (or the nearest) A/B alleles # of patients
(%)
sTIL, mean (95% CI) P-value
rs1051740 chr1:225831932 EPHX1 C/C 195 (20.1) 28.31 (23.45, 33.93) 0.037
T/C 472 (48.7) 28.81 (22.92, 36.72)
T/T 295 (30.4) 27.01 (20.71, 34.22)
Missing 7 (0.7)
rs1312200 chr4:99091206 LOC100507053 C/C 443 (45.7) 27.23 (21.51, 34.04) 0.001
T/T 409 (42.2) 29.90 (23.31, 36.90)
C/T 107 (11.0) 26.32 (22.28, 33.22)
Missing 10 (1.0)
rs3762894 chr4:99144933 ADH4 C/C 437 (45.1) 27.37 (21.47, 34.08) 0.002
LOC100507053 C/T 406 (41.9) 29.66 (23.51, 36.76)
T/T 107 (11.0) 26.39 (22.39, 33.33)
Missing 19 (2.0)
rs2051428 chr4:99202029 LOC100507053 C/C 496 (51.2) 27.53 (21.61, 34.09) 0.004
C/T 382 (39.4) 29.61 (23.39, 36.90)
T/T 85 (8.8) 26.32 (22.17, 33.24)
Missing 6 (0.6)
rs10008281 chr4:99221145 ADH6 A/A 515 (53.1) 27.59 (21.64, 34.27) 0.009
A/C 368 (38.0) 29.58 (23.72, 36.92)
C/C 77 (7.9) 26.95 (22.17, 33.42)
Missing 9 (0.9)
rs10052657 chr5:59111944 PDE4D A/A 15 (1.5) 21.67 (17.12, 24.88) 0.008
C/C 212 (21.9) 28.55 (23.09, 34.13)
C/A 720 (74.3) 28.27 (22.43, 35.80)
Missing 22 (2.3)
rs2285947 chr7:21544470 DNAH11 A/A 73 (7.5) 24.32 (19.23, 32.05) 0.021
G/A 391 (40.4) 28.80 (22.63, 36.31)
G/G 474 (48.9) 28.06 (22.67, 35.00)
Missing 31 (3.2)
rs1799930 chr8:18400593 NAT2 A/A 41 (4.2) 31.55 (24.49, 36.96) 0.021
G/A 334 (34.5) 29.09 (23.17, 36.87)
G/G 554 (57.2) 27.36 (21.75, 34.07)
Missing 40 (4.1)
rs1800682 chr10:88990206 FAS C/C 127 (13.1) 27.41 (19.99, 34.01) 0.015
ACTA2 T/C 474 (48.9) 29.09 (23.14, 36.41)
T/T 348 (35.9) 27.43 (21.67, 34.31)
Missing 20 (2.1)
rs2234767 chr10:88989499 FAS A/A 108 (11.1) 26.93 (19.57, 33.65) 0.030
ACTA2 G/A 444 (45.8) 28.73 (23.14, 36.09)
G/G 401 (41.4) 27.76 (22.15, 35.03)
Missing 16 (1.7)