Table 2. Significant SNPs (P-values < 0.05) from a Kruskal-Wallis test for the association with ESCC (N=969).
SNP | Position | Gene (or the nearest) | A/B alleles |
# of patients (%) |
sTIL, mean (95% CI) | P-value |
rs1051740 | chr1:225831932 | EPHX1 | C/C | 195 (20.1) | 28.31 (23.45, 33.93) | 0.037 |
T/C | 472 (48.7) | 28.81 (22.92, 36.72) | ||||
T/T | 295 (30.4) | 27.01 (20.71, 34.22) | ||||
Missing | 7 (0.7) | |||||
rs1312200 | chr4:99091206 | LOC100507053 | C/C | 443 (45.7) | 27.23 (21.51, 34.04) | 0.001 |
T/T | 409 (42.2) | 29.90 (23.31, 36.90) | ||||
C/T | 107 (11.0) | 26.32 (22.28, 33.22) | ||||
Missing | 10 (1.0) | |||||
rs3762894 | chr4:99144933 | ADH4 | C/C | 437 (45.1) | 27.37 (21.47, 34.08) | 0.002 |
LOC100507053 | C/T | 406 (41.9) | 29.66 (23.51, 36.76) | |||
T/T | 107 (11.0) | 26.39 (22.39, 33.33) | ||||
Missing | 19 (2.0) | |||||
rs2051428 | chr4:99202029 | LOC100507053 | C/C | 496 (51.2) | 27.53 (21.61, 34.09) | 0.004 |
C/T | 382 (39.4) | 29.61 (23.39, 36.90) | ||||
T/T | 85 (8.8) | 26.32 (22.17, 33.24) | ||||
Missing | 6 (0.6) | |||||
rs10008281 | chr4:99221145 | ADH6 | A/A | 515 (53.1) | 27.59 (21.64, 34.27) | 0.009 |
A/C | 368 (38.0) | 29.58 (23.72, 36.92) | ||||
C/C | 77 (7.9) | 26.95 (22.17, 33.42) | ||||
Missing | 9 (0.9) | |||||
rs10052657 | chr5:59111944 | PDE4D | A/A | 15 (1.5) | 21.67 (17.12, 24.88) | 0.008 |
C/C | 212 (21.9) | 28.55 (23.09, 34.13) | ||||
C/A | 720 (74.3) | 28.27 (22.43, 35.80) | ||||
Missing | 22 (2.3) | |||||
rs2285947 | chr7:21544470 | DNAH11 | A/A | 73 (7.5) | 24.32 (19.23, 32.05) | 0.021 |
G/A | 391 (40.4) | 28.80 (22.63, 36.31) | ||||
G/G | 474 (48.9) | 28.06 (22.67, 35.00) | ||||
Missing | 31 (3.2) | |||||
rs1799930 | chr8:18400593 | NAT2 | A/A | 41 (4.2) | 31.55 (24.49, 36.96) | 0.021 |
G/A | 334 (34.5) | 29.09 (23.17, 36.87) | ||||
G/G | 554 (57.2) | 27.36 (21.75, 34.07) | ||||
Missing | 40 (4.1) | |||||
rs1800682 | chr10:88990206 | FAS | C/C | 127 (13.1) | 27.41 (19.99, 34.01) | 0.015 |
ACTA2 | T/C | 474 (48.9) | 29.09 (23.14, 36.41) | |||
T/T | 348 (35.9) | 27.43 (21.67, 34.31) | ||||
Missing | 20 (2.1) | |||||
rs2234767 | chr10:88989499 | FAS | A/A | 108 (11.1) | 26.93 (19.57, 33.65) | 0.030 |
ACTA2 | G/A | 444 (45.8) | 28.73 (23.14, 36.09) | |||
G/G | 401 (41.4) | 27.76 (22.15, 35.03) | ||||
Missing | 16 (1.7) |