Table 3. Univariate and multivariate cox regression analyses of SNPs for DFS (N=969).

SNP	Position	Gene (or the nearest)	A/B alleles	Count	Median survival (days)	Univariate analysis			Multivariate analysis
						P-value	HR (95% CI)		P-value	HR (95% CI)
rs1801131	chr1:11794419	MTHFR	A/A	632	1003	0.018	Ref.
			A/C	256	744		1.238(1.030-1.488)		0.151	1.151(0.950-1.394) a
			C/C	30	649		1.537(1.008-2.343)		0.007	1.869(1.183-2.954) a
rs994771	chr4:99406646	LOC102723576	C/C	106	667	0.048	Ref.
			T/C	385	909		0.779(0.600-1.012)		0.079	0.781(0.594-1.029) a
			T/T	458	993		0.723(0.559-0.936)		0.065	0.776(0.593-1.016) a
rs2234767	chr10:88989499	FAS	A/A	108	776	0.004	Ref.
		ACTA2	G/A	444	1172		0.771(0.591-1.007)		0.052	0.761(0.578-1.002) b
			G/G	401	791		1.024(0.787-1.333)		0.850	0.974(0.742-1.279) b
rs1800682	chr10:88990206	FAS	C/C	127	899	0.023	Ref.
		ACTA2	T/C	474	1037		0.860(0.668-1.107)		0.159	0.828(0.638-1.076) b
			T/T	348	790		1.100(0.851-1.422)		0.958	1.007(0.772-1.315) b
rs8030672	chr15:68766745	ANP32A	T/A	62	1734	0.018	Ref.
			T/T	905	883		1.596(1.085-2.350)		0.029	1.545(1.045-2.284) a
rs25487	chr19:43551574	XRCC1	A/A	43	783	0.001	Ref.
			G/A	354	700		0.948(0.651-1.379)		0.632	0.910(0.619-1.338) a
			G/G	553	1078		0.704(0.487-1.019)		0.014	0.619(0.424-0.906) a

Abbreviations: DFS, disease-free survival; CI, confidence interval; HR, hazard ratio.

^awith adjustment for sTIL, age, sex, grade of differentiation, first-line treatment method, BMI.

^bwith adjustment for age, sex, grade of differentiation, first-line treatment method, BMI.