Table 4. Univariate and multivariate cox regression analyses of basic characteristics with DFS in ESCC (N=969).
| Characteristics | No. of patients (%) | Median survival (days) | Univariate analysis | Multivariate analysis | |||
| P-value | HR (95% CI) | P-value | HR (95% CI)a | ||||
| sTIL, mean(range) | 28.80 (3.25-69.55) | <0.001 | 0.955(0.946-0.963) | <0.001 | 0.958(0.949-0.967) | ||
| Age, mean(range) | 67 (42-85) | <0.001 | 1.025(1.015-1.035) | 0.023 | 1.014(1.002-1.025) | ||
| Sex | |||||||
| Male | 645 (66.6) | 855 | Ref. | Ref. | |||
| Female | 324 (33.4) | 1074 | 0.035 | 0.875(0.773-0.991) | 0.017 | 0.756(0.601-0.951) | |
| First-degree family history of ESCC | |||||||
| No | 640 (66.0) | 909 | Ref. | Ref. | |||
| Yes | 299 (30.9) | 918 | 0.550 | 0.962(0.849-1.091) | 0.262 | 0.926(0.81-1.059) | |
| Missing | 30 (3.1) | ||||||
| Grade of Differentiation | |||||||
| Gx Grading cannot be evaluated | 49 (5.1) | 598 | Ref. | Ref. | |||
| G1 Highly differentiated | 72 (7.4) | 1614 | <0.001 | 1.195(0.886-1.611) | 0.837 | 1.034(0.754-1.418) | |
| G2 Medium differentiation | 563 (58.1) | 1078 | 1.737(1.339-2.253) | 0.006 | 1.463(1.113-1.923) | ||
| G3 Poorly differentiated | 181 (18.7) | 750 | 0.724(0.547-0.957) | 0.164 | 0.813(0.607-1.088) | ||
| G4 Undifferentiated | 63 (6.5) | 514 | 1.12(0.91-1.378) | 0.304 | 1.12(0.902-1.39) | ||
| Missing | 41 (4.2) | ||||||
| First-line treatment method | |||||||
| Chemotherapy | 120 (12.4) | 531 | Ref. | Ref. | |||
| Surgery | 468 (48.3) | 1517 | <0.001 | 0.454(0.356-0.578) | <0.001 | 0.588(0.449-0.77) | |
| Radiotherapy | 117 (12.1) | 562 | 0.892(0.664-1.2) | 0.809 | 0.961(0.695-1.329) | ||
| Combination therapy | 221 (22.8) | 710 | 0.783(0.603-1.017) | 0.875 | 0.977(0.732-1.305) | ||
| Untreated | 39 (4.0) | 352 | 1.772(1.2-2.617) | 0.109 | 1.485(0.915-2.409) | ||
| Missing | 4 (0.4) | ||||||
| BMI | |||||||
| <18.5 | 102 (10.5) | 619 | Ref. | Ref. | |||
| [18.5,24) | 619 (63.9) | 791 | <0.001 | 0.599(0.411-0.872) | 0.192 | 0.772(0.523-1.139) | |
| [24,28) | 219 (22.6) | 1351 | 1.159(0.861-1.561) | 0.344 | 1.161(0.852-1.583) | ||
| ≥28 | 29 (3.0) | 1217 | 1.103(0.913-1.333) | 0.100 | 1.183(0.968-1.446) | ||
| Smoking(pack-years) | |||||||
| Never | 400 (41.3) | 1018 | Ref. | Ref. | |||
| <30.0 | 224 (23.1) | 786 | 0.141 | 1.006(0.876-1.154) | 0.101 | 0.845(0.69-1.034) | |
| ≥30.0 | 304 (31.4) | 930 | 0.856(0.733-0.999) | 0.271 | 0.902(0.75-1.084) | ||
| Missing | 41 (4.2) | ||||||
| Alcohol consumption status | |||||||
| No | 466 (48.1) | 879 | Ref. | Ref. | |||
| Still drinking now | 464 (47.9) | 936 | 0.487 | 0.943(0.799-1.113) | 0.187 | 0.859(0.685-1.077) | |
| Missing | 39 (4.0) | ||||||
| Tea drinking | |||||||
| No | 628 (64.8) | 930 | Ref. | Ref. | |||
| Yes | 303 (31.3) | 844 | 0.430 | 1.051(0.929-1.189) | 0.004 | 1.264(1.079-1.481) | |
| Missing | 38 (3.9) | ||||||
| Times of tooth brushing daily | |||||||
| ≤1 | 774 (79.9) | 912 | Ref. | Ref. | |||
| >1 | 169 (17.4) | 950 | 0.983 | 1.002(0.862-1.164) | 0.435 | 1.068(0.905-1.26) | |
| Missing | 26 (2.7) | ||||||
| Wealth score | |||||||
| Q1 | 299 (30.9) | 781 | Ref. | Ref. | |||
| Q2 | 181 (18.7) | 844 | 0.401 | 0.831(0.673-1.027) | 0.149 | 0.833(0.65-1.068) | |
| Q3 | 221 (22.8) | 936 | 0.992(0.811-1.213) | 0.808 | 0.972(0.772-1.223) | ||
| Q4 | 170 (17.5) | 952 | 0.928(0.762-1.131) | 0.293 | 0.89(0.716-1.106) | ||
| Q5 | 98 (10.1) | 1180 | 1.003(0.836-1.203) | 0.125 | 0.857(0.704-1.044) | ||
| Education level | |||||||
| Illiteracy | 360 (37.2) | 735 | Ref. | Ref. | |||
| Primary school | 368 (38.0) | 986 | 0.073 | 0.828(0.638-1.074) | 0.200 | 0.807(0.582-1.12) | |
| Junior high school | 186 (19.2) | 1003 | 1.105(0.883-1.381) | 0.510 | 1.088(0.847-1.399) | ||
| High school and above | 55 (5.7) | 1288 | 1(0.836-1.196) | 0.579 | 0.946(0.778-1.15) | ||
Abbreviations: DFS, disease-free survival; CI, confidence interval; HR, hazard ratio.
awith adjustment for sTIL, age, sex, grade of differentiation, first-line treatment method, BMI.