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A schematic diagram of the possible mechanism of gastrodin improving cognitive impairment in vascular dementia rats by promoting autophagy flux through inhibiting Ca2+/CaMKII signal pathway. GAS improves cognitive dysfunction in a VD rat model. GAS ameliorates the CoCl2-induced suppression of autophagic flux by lowering [Ca2+]i-dependent CaMKII phosphorylation in HT22 cells, reduces apoptosis in HT22 cells.
