Table 1.
Study measures and correlating data collection source for WHF Global study on COVID-19 and CVD.
| Study Measure | Details | Data collection source |
|---|---|---|
| PART 1: ENTRY FORM | ||
| Demographics | Age, sex, ethnicity, education, smoking status, pregnancy status | eCRF & hospital records |
| COVID-19 symptom onset and admission vital signs | Symptom onset, admission date, temperature, oxygen, respiratory rate, blood pressure, height, weight, waist circumference, shortness of breath | eCRF & hospital records |
| Comorbidities (cardiovascular related prior to admission) | Coronary artery disease, stroke, peripheral vascular disease, atrial fibrillation, heart failure, cardiomyopathies, rheumatic heart disease, chagas disease, valvular disease, hypertension, diabetes | eCRF & hospital records |
| Comorbidities (non-cardiac related prior to admission) | Chronic pulmonary disease, asthma, tuberculosis, HIV, renal replacement therapy, chronic kidney disease | eCRF & hospital records |
| Cardiovascular medication (Pre-admission) | Beta-blockers, alpha blockers, diuretics, ACE-inhibitors, anti-coagulants, anti-platelets, ARB, calcium antagonists, aldosterone antagonists, endocarditis prophylaxis, nitrates, statins | eCRF & hospital records |
| Non-cardiovascular medication (Pre-admission) | Anti-diabetic drugs, NSAIDS, allopurinol, anti-depressants, anti-retroviral therapy, influenza vaccine in the past 6 months | eCRF & hospital records |
| Laboratory tests on admission | Complete blood count, liver function tests, kidney function tests, cardiac biomarkers (Troponin-T, I, NT proBNP, CK-MB), lipids | eCRF & Lab reports |
| Examinations | ECG, ECHO, Chest-X-ray, CT-Scan Anonymized ECG data will be uploaded to a web-based platform to be read and codified in a centralized reading centre by experienced and certified cardiologists. |
eCRF & hospital records |
| Medications during hospitalization | Intravenous fluids, antivirals, ACE-I, ARB, NSAIDS, antibiotics, anti-malarial agent, anti-fungal agent, corticosteroids | eCRF & hospital records |
| Supportive care during hospitalization | ICU admission, oxygen therapy, non-invasive and invasive ventilation, inotropes, extracorporeal support | eCRF & hospital records |
| PART 2: OUTCOME FORM | ||
| At discharge | Blood pressure, heart rate, time in ICU, cardiovascular events, acute respiratory distress syndrome, pneumonia, acute renal injury, liver dysfunction, death (cause of death) | eCRF & discharge summary |
| 30-day follow-up | Vital stats (alive or death), re-hospitalization, recovery from COVID-19 | Phone or clinic visit |
| Hospital and Provider level information | Hospital facilities (hospital beds, ICU, ventilators), availability of services (ECG, ECHO, x-ray, CT-scan, cardiac cath lab) human resources (cardiologists, pulmonologists, infectious disease specialists) | Hospital records |
ACEi = angiotensin-converting enzyme inhibitor, ARB = angiotensin II receptor blocker, ECG = electrocardiogram, ICU = intensive care unit, NSAIDS = non-steroidal anti-inflammatory drugs.