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. 2021 Mar 24;13(4):544. doi: 10.3390/v13040544

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Comparison of detectable epigenetic marks in HIV+ prefrontal cortex specimens. Using ChIP-qPCR, we tested our ability to detected genomic marks in postmortem human prefrontal cortex tissue with low RNA quality. (A) RNAPol, H3K27Ac and H3K4me3 were detected in 3 amplified genomic regions: A desert sequence in the human chromosome 12 was used as negative control (white bars), ACTB (gray bars) and GAPDH (black bars) promoters. * p < 0.05 compared to Untr12 negative control. (B) H3K4me3 peaks in the GAPDH genomic sequence in representative postmortem specimens from both groups. * p < 0.05 in comparisons indicated by lines.