Table 3.
List of 10 most frequent transcription factor binding motifs identified in +/−200 bp from and within H3K4me3 intervals in HIV+ Meth- and Meth+ specimens. The most frequent consensus sequences are presented, along with the average number of binding sites per interval sequence throughout the genome.
| Matrix | Factor | Consensus Sequence | Classification | Average #Sites Interval Sequence |
|---|---|---|---|---|
| V$SP1_13 | Sp1 | gcggctctgcggGGCGGggcgggg | ZFC2H2 | 4.33 |
| V$P53_03 | P53 | cgACATGGacacacatgggt | P53 | 3.33 |
| V$ETS2_06 | c-Ets-2 | ggCCGGAgaggctgcccctt | ETS | 2.85 |
| V$JUNDFRA2_01 | JUND:FRA2 | aaTGACTcaa | BZIP | 2.5 |
| V$ASCL1_03 | MASH-1 | cgCAGCTgcc | BHLH | 2.5 |
| V$NR3C1_13 | GR | aacacaataTGTACa | ZFC4-NR | 2.33 |
| V$CREBP1_01 | ATF-2 | tgaCGTCA | BZIP | 2.29 |
| V$AP2ALPHA_03 | AP2aA | cgCGCCCccggctct | BHSH | 2.27 |
| V$MYCMAX_03 | cMyc:Max | agttatgcACGTGtgtacca | BHLH | 2.15 |
| V$HOXA5_03 | HOXA5 | AATTAgtg | HOX | 2 |