Figure 7.

Schematic illustrating the suppressive effect of 6M3HSC (compound 3) against the RAGE-RAGE ligand signaling pathway. A potential mechanism of the suppressive effect of this compound 3 on HMGB1-RAGE-ERK 1/2 signaling pathway is shown. The interactions of multi-ligands with RAGE up-regulate the RAGE downstream signaling pathway. Consequently, RAGE-regulated genetic programs of pro-inflammation and carcinogenesis (TEM and oncogenesis) or cell repair and tissue regeneration (homeostasis and ontogenesis) start driving by the action of transcription factors, such as NF-κB and AP-1. RAGE structure includes the variable (V), constant (C₁ and C₂) domains, the transmembrane region (TM), and the cytoplasmic tail (CT).