Table 4.

Time to peak pain relief.

	TTX Dosage
	7.5 µg BID N = 25	15 µg BID N = 24	30 µg QD N = 25	30 µg BID N = 26	Placebo N = 25
Time to Peak Pain Relief a
n	23	24	23	25	25
Mean change (Weeks) (±SD)	2.5 (±1.2)	2.4 (±1.2)	3.0 (±1.2)	2.6 (±1.3)	2.5 (±1.1)
Kaplan–Meier Estimate of weeks to peak pain relief
Median (Weeks) (95% CI)	3.00 (1.00, 3.00)	2.50 (1.00, 3.00)	3.00 (3.00, 4.00)	3.00 (1.00, 4.00)	3.00 (1.00, 3.00)

CI: confidence interval; NPRS: Numerical Pain Rating Scale; SD: standard deviation; TTX: tetrodotoxin; BID: twice daily; QD: once daily; n: number of subjects. Note: Time to peak pain relief defined as the time from first dose of study medication to the date of the maximum pain relief. Week 1 = Days 1 to 7, Week 2 = Days 8 to 14, Week 3 = Days 15 to 21, Week 4 = Days 22 to 28. ^a Subjects who withdrew from the study early or subjects who completed the study but took rescue on their last visit were censored at their last visit with the last non-missing average pain score.