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. 2021 Mar 25;13(4):442. doi: 10.3390/pharmaceutics13040442

Figure 5.

Figure 5

Combination with GNPs and cisplatin in RT. (a) Cell survival fraction of MDA-MB-231 cells treated with cisplatin (CIS) and GNP- arginine-glycine-aspartic acid (RGD); CIS prior to 2 Gy, 6 MV radiation. Data are means ± S.E.M. for n = 3. * represents statistically significant difference (unpaired t-test, p < 0.05); (b) Qualitative representation of DNA double-strand breaks (DSBs) in MDA-MB-231 cells treated with CIS and GNP-RGD; CIS prior to 2 GY, 6 MV X-ray radiation. The nucleus is stained with DAPI (shown in blue) and the markers for DNA DSBs, 53BP1, are shown in green. Scale bar = 10 µm; (c) Quantitative analysis of (b). Reproduced from [68], MDPI, 2018.