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. 2021 Mar 25;9(4):331. doi: 10.3390/biomedicines9040331

Figure 1.

Figure 1

Reduction in Renal Interstitial Injury and Fibrosis in UUO Mouse Kidneys due to STAT3 Decoy ODNs. The effects of STAT3 decoy ODNs on histological alterations after UUO. (A) The kidney sections stained with hematoxylin and eosin (H&E) stain and the Masson’s trichrome stain. (B) Quantitative analysis of the interstitial collagen area of each group (n = 3) and performed at a magnification of 400X. The results are expressed as means ± SE of three independent determinations * p < 0.05 vs. NC, † p < 0.05 vs. UUO; NC, normal control group; STAT3, STAT3 decoy injection to normal control group; UUO, UUO surgery group; Scr, scramble ODN injection to UUO surgery group; UUO + STAT3, STAT3 decoy ODN injection to UUO surgery group. Abbreviations: UUO, unilateral ureteral obstruction; decoy ODNs, decoy oligonucleotides; STAT3, signal transducer and activator of transcription 3; Scr, scrambled.