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. 2021 Mar 25;9(4):331. doi: 10.3390/biomedicines9040331

Figure 6.

Figure 6

Induction of the PI3K-Akt-mTOR Pathway in a UUO Mouse Model with STAT3 Decoy ODN Injection. The PI3k-Akt-mTOR signaling pathway was increased in UUO mouse model with STAT3 decoy injection. Western blot data show the PI3K-Akt-mTOR pathway. The expression of p-PI3K, p-Akt, and p-mTOR decrease in UUO and autophagy induces in UUO mouse model. Abbreviations: UUO, unilateral ureteral obstruction; decoy ODNs, decoy oligonucleotides; STAT3, signal transducer and activator of transcription 3; Scr, scrambled; PI3K, phosphoinositide 3-kinase; Akt, protein kinase B; mTOR, mammalian target of rapamycin.