Figure 2.

Brief illustration of B-cell development. miRNAs with a positive impact on the procedure are shown in green font, while those with a negative impact are shown in red. Black color indicates a miRNA with a controversial impact on B-cell development. miRNA targets are shown in purple font. Light blue arrows indicate the transition to the next developmental stage of B cells; dark blue “reverse tau” symbols (⊥) indicate attenuation of expression, whereas green arrows indicate induction of expression. Abbreviations: CLP, common lymphoid progenitor; FO B, follicular B cell; GC B, germinal center B cell; HSC, hematopoietic stem cell; MZ B, marginal zone B cell.