Skip to main content
. 2021 Mar 25;9(4):333. doi: 10.3390/biomedicines9040333

Figure 3.

Figure 3

One of the potential effects of miR-16-5p in normal B cells (A) and follicular lymphoma (FL) B cells without t(14;18) (B). In the physiological state, its expression levels are high; miR-16-5p suppresses the expression levels of its target genes, CHEK1 and CDK6, leading to apoptosis and cell cycle arrest. On the contrary, in a FL B cell, the expression levels of miR-16-5p are low, leading to increased expression of its targets. This results in B-cell apoptosis inhibition and increased proliferation rate, two hallmarks of a malignant cell. Black arrows indicate the transition to the next step; red “reverse tau” symbols (⊥) indicate inhibition, whereas green arrows indicate promotion of a cellular process. Abbreviations: BCR, B-cell receptor; RISC, RNA-induced silencing complex.