. 2021 Mar 25;9(4):333. doi: 10.3390/biomedicines9040333

Table 5.

Potential interactions between miRNAs that are deregulated in indolent B-cell NHLs and their validated targets in other malignancies.

Disease	miRNAs	Potential Target in Lymphomas	Potential Effect in B Cells	References
Gastric MALT lymphoma	miR-150-5p	MYB	Regulation of B-cell development	[14,76,100,101]
	miR-150-5p	EGR2	Inhibition of apoptosis	[14,76,100,101]
	miR-196a-5p	CDKN1B	Promotion of cell cycle	[76,104]
	miR-153-3p	AKT3	Inhibition of cell proliferation	[76,105]
	miR-7-5p	EGFR and IGF1R	Inhibition of metastasis	[76,106,107]
	miR-16-5p	BCL2	Promotion of apoptosis	[113,114]
Splenic MZL	miR-29a/b1 cluster	TCL1A	Inhibition of cell proliferation	[126,128,129,130,131]
	miR-129-5p	BCL2	Promotion of apoptosis	[126,128,129,130,131]
	miR-21-5p	PTEN, FOXO3	Promotion of cell proliferation, inhibition of apoptosis	[133,134]
Nodal MZL	miR-223-3p	LMO2	Inhibition of B-cell differentiation	[42,139]
OAL	miR-29 family	TCL1A	Inhibition of cell proliferation	[118,119]
		CDK6	Inhibition of cell proliferation
		DNMT3B	Inhibition of DNA methylation
		MCL1	Promotion of apoptosis
	miR-199a-5p	IKBKB	Promotion of apoptosis	[118,120,121]
WM	miR-9-3p	PDRM1	Inhibition of B-cell differentiation	[149]
	miR-125b-5p and miR-181a-5p	PRDM1, IRF4	Inhibition of B-cell differentiation	[149]
	let-7a-5p	MYC	Inhibition of cell proliferation	[142]
	miR-21-5p	PTEN, PDCD4	Promotion of cell proliferation, regulation of apoptosis	[150]
PCFCL	miR-9-5p	PRDM1	Inhibition of B-cell differentiation	[148]
	miR-129-2-3p	SOX4
	miR-155-5p	SPI1

Abbreviations: MALT, mucosa-associated lymphoid tissue; MZL, marginal zone lymphoma; OAL, Ocular adnexal lymphoma; PCFCL, primary cutaneous follicle center lymphoma; WM, Waldenström’s macroglobulinemia.