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. 2021 Apr 23;16(4):e0248380. doi: 10.1371/journal.pone.0248380

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© 2021 Mrozek et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 9 — Xenograft tumors generated from SNU-398 cells were harvest 24h after ganetespib treatment, 6h after INK 128 and rapamycin treatment, and stained using H&E, pS6 (S235/236), TSC2, ApopTag, or PCNA antibodies. Images shown were 60X magnified, insets showed portions of the tumor at higher magnification (400X). Tumors showed a distinct vascularization. TSC2 was not expressed in any tumor. PS6 (S235/236) expression was stronger in vehicle- and ganetespib-treated mice and correlated with locations of higher proliferation.