Table 2. IC50 determination of the most effective drugs.
| IC50 in nM for cell line | ||||||
|---|---|---|---|---|---|---|
| inhibitor | target | PEER | CAL-72 | SNU-878 | SNU-886 | SNU-398 |
| Rapamycin | mTORC1 | NR | NR | NR | NR | NR |
| WYE-125132 | mTORC1/2 | >10000 | 31 | 55 | 55 | 58 |
| AZD8055 | mTORC1/2 | >10000 | 40 | 38 | 52 | 73 |
| Torin1 | mTORC1/2 | 844 | 37 | 300 | 120 | 340 |
| Torin2 | mTORC1/2/PI3Ks/DNA-PK | 40 | 6 | 12 | 9 | 19 |
| INK128 | mTORC1/2 | 102 | 44 | 23 | 30 | 67 |
| CGP60474 | CDKs, mTOR | 46 | 41 | 50 | 36 | 24 |
| Flavopiridol | pan-CDKs | 179 | 123 | 172 | 121 | 68 |
| BMS-387032 | CDKs | 245 | 408 | 949 | 978 | 95 |
| GSK2126458 | PI3K | 925 | 39 | 25 | 10 | 103 |
| GSK461364 | PLK | 3454 | >10000 | 33 | 5 | 6 |
| HMN-214 | PLK | 82 | 1208 | 171 | 193 | 223 |
| WZ3105 | CLK2/CNSK1E/FLT3/ULK1 | 108 | 322 | 1515 | 1254 | 60 |
| PF477736 | CHK1 | 29 | ND | ND | ND | 25 |
| AZD7762 | CHKs | 50 | 185 | 25 | 71 | 124 |
| MK 1775 | Wee1 | 207 | 364 | 86 | 354 | 144 |
| Chelerythrine chloride | PKC | 148 | ND | ND | ND | 2532 |
| SB525334 | TGFBR1 | 6 | ND | ND | ND | >10000 |
| GSK1070916 | AuroraA,B,C | 2 | ND | ND | ND | 3103 |
| ZM-447439 | AuroraA,B | 156 | ND | ND | ND | 672 |
| AZD1152-HQPA | AuroraA,B,C | 7 | ND | ND | ND | >10000 |
| XMD16-144 | AuroraA,B | 4 | ND | ND | ND | 552 |
| NVP-AUY922 | HSP90 | 2 | 9 | 12 | 10 | 10 |
| Ganetespib | HSP90 | 3 | 22 | 14 | 35 | 9 |
NR, IC50 not reached at 10μM. ND, not done.