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. 2021 Apr 23;16(4):e0248380. doi: 10.1371/journal.pone.0248380

Table 3. IC50 determination of Torin2, Ganetespib and combination therapy.

IC50 in nM for cell line
inhibitor target PEER CAL-72 SNU-878 SNU-886 SNU-398
Torin2 mTORC1/2/PI3Ks/DNA-PK 40 6 12 9 19
Ganetespib HSP90 3 22 14 35 9
 Ganetespib + Torin2 (fixed at 5nM) 6 20 8 9 4
 Ganetespib + Rapamycin (fixed at 20nM) 6 17 6 5 2