Table 3. IC50 determination of Torin2, Ganetespib and combination therapy.
IC50 in nM for cell line | ||||||
---|---|---|---|---|---|---|
inhibitor | target | PEER | CAL-72 | SNU-878 | SNU-886 | SNU-398 |
Torin2 | mTORC1/2/PI3Ks/DNA-PK | 40 | 6 | 12 | 9 | 19 |
Ganetespib | HSP90 | 3 | 22 | 14 | 35 | 9 |
Ganetespib + Torin2 (fixed at 5nM) | 6 | 20 | 8 | 9 | 4 | |
Ganetespib + Rapamycin (fixed at 20nM) | 6 | 17 | 6 | 5 | 2 |